FN Clarivate Analytics Web of Science VR 1.0 PT J AU Pulopulos, MM Kozusznik, MW AF Pulopulos, Matias M. Kozusznik, Malgorzata W. TI The moderating role of meaning in life in the relationship between perceived stress and diurnal cortisol SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS LA English DT Article DE Perceived stress; meaning in life; diurnal cortisol slope; diurnal cortisol levels; HPA axis ID SALIVARY CORTISOL; AWAKENING RESPONSE; COGNITIVE PERFORMANCE; POSITIVE HEALTH; MARITAL-STATUS; PURPOSE; EVENTS; WOMEN; METAANALYSIS; DEPRESSION AB Previous studies have suggested that meaning in life may buffer the negative effects of stress. This study is the first to investigate the moderating role of meaning in life in the relationship between the perception of stress and diurnal cortisol in two independent samples of healthy adults. In study 1 (n=172, men=82, women=90, age range=21-55years, mean age=37.58years), the results of moderated regression analyses revealed that there was a significant positive relationship between overall perceived stress in the past month and both diurnal cortisol levels (area-under-the-curve with respect to the ground; AUCg) and the diurnal cortisol slope (DCS) only in individuals with low levels of meaning in life conceptualized as the degree to which one engages in activities that are personally valued and important. In study 2 (n=259, men=125, women=134, age range=18-54years, mean age=29.06years), we found a non-significant interaction term between meaning in life conceptualized as having goals and a sense of excitement regarding one's future and perception of stress in a model of both adjusted AUCg and DCS. The results were independent of age, sex, body mass index, education, and race. The results shed light on the importance and the complexity of the construct of meaning in life and offer a possible explanation for why some people who face stressors may be more vulnerable than others to developing stress-related health problems. C1 [Pulopulos, Matias M.] Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium. [Kozusznik, Malgorzata W.] Katholieke Univ Leuven, Res Grp Work Org & Personnel Psychol WOPP, Leuven, Belgium. [Kozusznik, Malgorzata W.] Univ Valencia, IDOCAL, Valencia, Spain. RP Pulopulos, MM (reprint author), Univ Ghent, Dept Expt Clin & Hlth Psychol, Fac Psychol & Educ Sci, Henri Dunantlaan 2, B-9000 Ghent, Belgium.; Kozusznik, MW (reprint author), Katholieke Univ Leuven, Fac Psychol, Dekenstr 2,PO 3725, B-3000 Leuven, Belgium. EM matias.pulopulos@ugent.be; malgorzata.kozusznik@uv.es FU National Center for Complementary and Integrative Health [NCCIH AT006694]; National Heart, Lung, and Blood Institute [NHLBI HL65111, NHLBI HL65112]; National Institute of Mental Health [NIMH MH50429]; National Cancer Institute Cancer Center Support Grant [P30CA047904]; National Institutes of Health [NIH 5M01 RR00056]; Special Research Fund (BOF) at Ghent University [01P18916]; Climate-KIC INN_TBE: Building technologies accelerator (BTA) [CPI-14-372 [2014/10500]] FX CCP data are made publically available through a grant from the National Center for Complementary and Integrative Health (NCCIH AT006694). The study was supported by grants from the National Heart, Lung, and Blood Institute (NHLBI HL65111 and NHLBI HL65112) and from the National Institute of Mental Health (NIMH MH50429). Secondary funding was provided by a National Cancer Institute Cancer Center Support Grant (P30CA047904) and by the National Institutes of Health (NIH 5M01 RR00056). Supplemental support was provided by the John D. and Catherine T. MacArthur Foundation Research Network on Socioeconomic Status & Health. Grants and funding sources had no further role in the analysis and interpretation of the data, in the writing of the report, or in the decision to submit the paper for publication. M.M.P. is a postdoctoral research fellow of the Special Research Fund (BOF; 01P18916) at Ghent University. During a part of the writing process of the manuscript, M.W.K. was a postdoctoral research fellow within the Climate-KIC INN_TBE: Building technologies accelerator (BTA), CPI-14-372 [2014/10500] grant. 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