FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Heeren, A
   Billieux, J
   Philippot, P
   De Raedt, R
   Baeken, C
   de Timary, P
   Maurage, P
   Vanderhasselt, MA
AF Heeren, Alexandre
   Billieux, Joel
   Philippot, Pierre
   De Raedt, Rudi
   Baeken, Chris
   de Timary, Philippe
   Maurage, Pierre
   Vanderhasselt, Marie-Anne
TI Impact of transcranial direct current stimulation on attentional bias
   for threat: a proof-of-concept study among individuals with social
   anxiety disorder
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE neuromodulation; transcranial direct current stimulation; attention bias
   modification; social anxiety disorder; prefrontal cortex; attentional
   bias
ID DORSOLATERAL PREFRONTAL CORTEX; SELECTIVE ATTENTION; ANGRY FACES;
   EMOTIONAL INFORMATION; MODIFICATION PROGRAM; NEURAL MECHANISMS; CAUSAL
   ROLE; PHOBIA; AMYGDALA; HEALTHY
AB Cognitive models posit that social anxiety disorder (SAD) is associated with and maintained by attentional bias (AB) for social threat. However, over the last years, it has been suggested that AB in SAD may result from a decreased activation of the left prefrontal cortex, and particularly of its dorsolateral part (dlPFC). Accordingly, a transient increase of neural activity within the left dlPFC via non-invasive brain stimulation decreases AB in non-anxious control participants. Yet, none of these studies focused on SAD. This is especially unfortunate as SAD constitutes the main target for which a genuine reduction of AB may be most appropriate. In this experiment, we sought to investigate the causal influence of left dlPFC neuromodulation on AB among 19 female individuals with a DSM-5 diagnosis of SAD. We adopted a double-blind within-subject protocol in which we delivered a single-session of anodal versus sham transcranial Direct Current Stimulation (tDCS) over the left dlPFC during the completion of a probe discrimination task assessing AB. Consistent with our hypothesis, participants demonstrated a significant decrease in AB during the anodal tDCS over the left DLPFC relative to the sham stimulation. These findings value tDCS as an innovative procedure to gain new insight into the underlying mechanisms of SAD.
C1 [Heeren, Alexandre] Harvard Univ, Dept Psychol, 1232 William James Hall,33 Kirkland St, Cambridge, MA 02138 USA.
   [Heeren, Alexandre; Billieux, Joel; Philippot, Pierre; de Timary, Philippe; Maurage, Pierre] Catholic Univ Louvain, Psychol Sci Res Inst, Louvain La Neuve, Belgium.
   [De Raedt, Rudi; Vanderhasselt, Marie-Anne] Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium.
   [Baeken, Chris; Vanderhasselt, Marie-Anne] Univ Ghent, Dept Psychiat & Med Psychol, Ghent, Belgium.
   [Baeken, Chris] Free Univ Brussels, Fac Med & Pharm, Brussels, Belgium.
   [de Timary, Philippe; Maurage, Pierre] Catholic Univ Louvain, Inst Neurosci, Brussels, Belgium.
   [de Timary, Philippe] Catholic Univ Louvain, Clin Univ St Luc, Dept Adult Psychiat, Brussels, Belgium.
   [Vanderhasselt, Marie-Anne] UZ Brussel, Univ Hosp Brussel, Fac Med & Pharm, Brussels, Belgium.
RP Heeren, A (reprint author), Harvard Univ, Dept Psychol, 1232 William James Hall,33 Kirkland St, Cambridge, MA 02138 USA.
EM alexandreheeren@fas.harvard.edu
FU Grant (F.R.S.-FNRS) from the Belgian National Fund for Scientific
   Research [FC78142]; Research Foundation Flanders [FWO08/PDO/168]; Ghent
   University [BOF16/GOA/017]; Belgian National Fund for Scientific
   Research (F.R.S.-FNRS); Belgian Foundation for Vocation (Vocatio); WBI
   World Excellence Grant [sub/2015/228106243177]; Ghent University
   Multidisciplinary Research Partnership 'The integrative neuroscience of
   behavioral control'
FX This research was supported by a Grant (F.R.S.-FNRS #FC78142) from the
   Belgian National Fund for Scientific Research (awarded to Alexandre
   Heeren), a Grant (FWO08/PDO/168) from the Research Foundation Flanders
   (awarded to Marie-Anne Vanderhasselt), and a Grant (BOF16/GOA/017) for a
   Concerted Research Action of Ghent University (awarded to Rudi De
   Raedt). Pierre Maurage is funded, as a research associate, by the
   Belgian National Fund for Scientific Research (F.R.S.-FNRS). This work
   also received the support from the Belgian Foundation for Vocation
   (Vocatio) and the WBI World Excellence Grant (sub/2015/228106243177),
   both awarded to Alexandre Heeren. This work was also supported by the
   Ghent University Multidisciplinary Research Partnership 'The integrative
   neuroscience of behavioral control'. These foundations did not exert any
   editorial direction or censorship on any part of this manuscript.
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NR 79
TC 1
Z9 1
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD FEB
PY 2017
VL 12
IS 2
BP 251
EP 260
DI 10.1093/scan/nsw119
PG 10
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA EP3WK
UT WOS:000397312200007
PM 27531388
ER

EF